NFL Week 6 Picks 2025: Florio vs Simms Showdown - Who Wins? (2025)

A thrilling Week 6 of the 2025 NFL season is upon us, and it's time to dive into the picks of the experts, Florio and Simms, as they go head-to-head! Last week was a rollercoaster, but this week promises to be even more exciting, with some controversial picks and intriguing matchups.

The Battle of the Experts: Who Will Reign Supreme?

Florio and Simms, two seasoned analysts, have had their fair share of disagreements this season. Last week, their predictions took a turn for the worse, with Florio managing a 4-10 record straight up, while Simms fared slightly better at 8-6. The spread, however, offered some relief, with Florio at 6-8 and Simms at 5-9.

But here's where it gets interesting: their lead in the overall standings has narrowed significantly. For the year, Florio boasts a 51-26-1 record straight up and a 44-34 record against the spread. Simms, on the other hand, is close behind with 49-28-1 and 39-39 records, respectively.

This week, the experts find themselves on the same page for most games, differing only on one match-up.

The Big Question: Can You Trust the Experts?

Florio, in his usual candid style, reminds us of the risks of wagering: "Please bet responsibly, and only with money you can afford to lose. After all, if you follow my advice, you might just lose it all!" A bold statement, indeed, but one that resonates with the unpredictable nature of sports betting.

Now, let's dive into their picks for Week 6, starting with a short week for the Eagles as they face the Giants.

Eagles (-7) at Giants:

Florio: Eagles 24, Giants 13. Can the Eagles finally get their offense on track? With a short week, it's now or never.

Simms: Eagles 27, Giants 17. A slightly higher score prediction, but Simms believes the Eagles will pull through.

Broncos (-7.5) vs. Jets at London:

Florio: Broncos 28, Jets 9. The Broncos have a chance to start their winning streak against a struggling Jets team.

Simms: Broncos 28, Jets 13. A similar prediction, with Simms expecting a more competitive game.

Rams (-7.5) at Ravens:

Florio: Rams 30, Ravens 13. The Ravens' luck seems to have run out, and the Rams are ready to pounce.

Simms: Rams 34, Ravens 17. Simms predicts a higher-scoring game, favoring the Rams.

Cowboys (-3) at Panthers:

Florio: Cowboys 27, Panthers 20. The Cowboys continue their relentless pursuit of contention.

Simms: Cowboys 31, Panthers 27. A closer game predicted by Simms, but still favoring the Cowboys.

Cardinals at Colts (-7):

Florio: Colts 27, Cardinals 17. One thing's for sure: we won't see a repeat of that infamous goal-line drop.

Simms: Colts 31, Cardinals 20. Simms expects a more dominant performance from the Colts.

Seahawks at Jaguars (-1.5):

Florio: Jaguars 21, Seahawks 17. The Jaguars are proving their mettle, and they're ready to take down a road-dominant Seahawks team.

Simms: Jaguars 34, Seahawks 24. A bold prediction from Simms, expecting a significant Jaguars victory.

Chargers (-4.5) at Dolphins:

Florio: Chargers 27, Dolphins 24. If not for injuries, this could be a blowout.

Simms: Chargers 23, Dolphins 20. A closer game predicted by Simms, but still favoring the Chargers.

Patriots (-3.5) at Saints:

Florio: Patriots 24, Saints 16. The Pats' playoff run is gaining momentum.

Simms: Patriots 28, Saints 17. Simms predicts a more comfortable win for the Patriots.

Browns at Steelers (-5.5):

Florio: Steelers 24, Browns 14. Aaron Rodgers vs. a rookie? The Browns might struggle.

Simms: Steelers 20, Browns 13. A closer game predicted, but Simms still favors the Steelers.

Titans at Raiders (-3.5):

Florio: Raiders 28, Titans 24. Tom Brady might be wishing for a refund after this one.

Simms: Raiders 20, Titans 13. Simms predicts a lower-scoring game, but still a Raiders victory.

Bengals at Packers (-14):

Florio: Packers 34, Bengals 17. A different quarterback, but the same result.

Simms: Packers 35, Bengals 20. Simms expects a higher-scoring game, favoring the Packers.

49ers at Buccaneers (-3):

Florio: Buccaneers 31, 49ers 27. The Bucs have arrived, and they're ready to make a Super Bowl run.

Simms: Buccaneers 24, 49ers 20. A closer game predicted, but Simms still believes in the Bucs.

Lions at Chiefs (-2.5):

Florio: Lions 30, Chiefs 24. Why are the Chiefs favored? The Lions might just pull off an upset.

Simms: Lions 30, Chiefs 21. Simms agrees, predicting a Lions victory.

Bills (-4.5) at Falcons:

Florio: Bills 23, Falcons 20. The Bills are vulnerable, but they should pull through.

Simms: Bills 24, Falcons 21. A close game predicted, with Simms favoring the Bills.

Bears at Commanders (-4.5):

Florio: Commanders 35, Bears 27. This is a rematch of the Commanders-Lions playoff game, and Dan Quinn is ready to outfox Ben Johnson again.

Simms: Bears 34, Commanders 31. Simms predicts an exciting, high-scoring game, favoring the Bears.

So, who will come out on top this week? Will Florio's predictions turn around, or will Simms continue his winning streak? Make sure to tune in and find out! And don't forget to share your thoughts and predictions in the comments below! Who do you think will reign supreme in Week 6?

NFL Week 6 Picks 2025: Florio vs Simms Showdown - Who Wins? (2025)
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